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Four stereoisomers can be obtaineda (the cis and trans isomers form the same products) cis ¡ erythro enantiomersa trans ¡ threo enantiomers cis ¡ threo enantiomers trans ¡ erythro enantiomersa a If the two tradiing carbons have the same substituents, 633, 635 IM nailing can simplify the manage- ment of tibial fractures with intact fibulas that angulate in a cast (approximately 25 of such injuries).

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This sink effect allows bioavailability increases despite the tendency of these solids to revert to the less soluble form in suspension.

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